If you’ve been clued into the peptides conversation, you might also be wondering what the best peptide skin-care products can do for you. This “silent powerhouse” (there are, in fact, various types of peptides) is a derm favorite for healing skin, slowing aging, and stimulating collagen and elastic production. At their most basic, peptides are short chains of amino acids that form the building blocks of proteins like collagen, elastin, and keratin. These proteins are essential for firm, youthful-looking skin.

Vogue’s Favorite Peptide Skin-Care Products:

According to board-certified dermatologist Brendan Camp, MD, peptides are garnering a lot of attention right now because they offer a range of skin benefits without being harsh or irritating. Unlike some ingredients that have had their moment in the spotlight and since faded from focus, peptides tend to be well-tolerated and easy to incorporate into a daily routine, which is why they are likely here to stay. He also notes that peptides can be especially helpful during post-procedure recovery, since they support the skin barrier and aid overall healing.

Much of their current popularity comes from a broader shift toward barrier-first skin care and gentler, long-term actives, as consumers move away from harsh, high-intensity routines. Though peptides are often touted as a “miracle” ingredient by the hyperbolic, Dr. Camp says their benefits are more gradual than immediate. “They help the skin improve collagen and elastin function over time, but consistent use is key,” he says. And while “peptides” has become something of a catchall term, there are actually several different types used in skincare, each serving a distinct purpose. Signal peptides, for example, encourage skin cells to produce more collagen, while carrier peptides help deliver trace minerals that support skin function and repair. Most formulas combine multiple peptides to help target firmness, elasticity, and overall skin health from several angles.

Below, we asked experts to explain what peptides are, whether they recommend them in a skin-care routine, and what to look for when shopping for the best peptide skin-care products, from creams and serums, to essences.

Best Peptide Serum: Medik8 Liquid Peptides Advanced MP

• Why We Love It: If you want to supercharge your skin-care routine, Dr. Ruth says, “this is a more high-tech serum featuring a 30% peptide complex that is formulated with micro molecules to better penetrate into the skin.” While it’s on the pricier side, she explains that it’s a great option for patients looking to smooth fine lines while also hydrating the skin and adding a healthy glow. Unlike some skin-care products that take time to show results, this one delivers noticeably plumper, more hydrated skin within a week.
• Editor’s Experience: “This is like the older sister of my go-to peptides serum—Medik8’s Liquid Peptides. This one amplifies the benefits via 13 peptides, a growth factor mini protein, an expression line mini protein, and hyaluronic acid for an incredibly potent, yet gentle cocktail.” —Kiana Murden, beauty editor, shopping
• Key Ingredients: Expression Line MiniProtein, Growth Factor MiniProtein, 30% Multi-Peptide Complex
• Best For: Mature skin
• Fragrance-Free: Yes
• Size: 1 fl oz